When examining the chromosomes, Ritossa found a "puffing pattern" that indicated the elevated gene transcription of an unknown protein. Heat shock was originally discovered by Ferruccio Ritossa in the 1960s when a lab worker accidentally boosted the incubation temperature of Drosophila (fruit flies). Members of the Hsp70 family are very strongly upregulated by heat stress and toxic chemicals, particularly heavy metals such as arsenic, cadmium, copper, mercury, etc. Additionally, membrane-bound Hsp70s have been identified as a potential target for cancer therapies and their extracellularly localized counterparts have been identified as having both membrane-bound and membrane-free structures. Intracellularly localized Hsp70s are an important part of the cell's machinery for protein folding, performing chaperoning functions, and helping to protect cells from the adverse effects of physiological stresses. Proteins with similar structure exist in virtually all living organisms. The 70 kilodalton heat shock proteins ( Hsp70s or DnaK) are a family of conserved ubiquitously expressed heat shock proteins. This imbalance leads to disease progression. The protective intracellular HSP70 is decreased whereas the levels of inflammatory extracellular HSP70 is increased. Schematic diagram highlighting the role of HSP70 in pathologies. Send us feedback about these examples.Structure of the ATPase fragment of a 70K heat-shock cognate protein. These examples are programmatically compiled from various online sources to illustrate current usage of the word 'chaperone.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Jim Higgins, Journal Sentinel, 20 June 2023 See More Lucy Evans, Scientific American, 22 June 2023 Each parent or guardian may only chaperone up to six minors per day. Joe Mutascio, The Indianapolis Star, 27 June 2023 So Cecilia would ride her bicycle into the lab chaperoned and in a full-length dress and hat as was expected for a woman to be seen in town. How to enter the mullet contest To be considered, anyone interested in competing has to submit an application here. Michael O'Sullivan, Washington Post, 20 June 2023 State Fair curfew:New Indiana State Fair policy requires youth under 18 to be chaperoned after 6 p.m. Alida Becker, New York Times, 28 July 2023 The main story concerns the relationship - if that’s even the right word, in a tale in which everyone seems to be merely going through the motions - between Augie and Midge, who are chaperoning their respective kids (Jake Ryan and Grace Edwards) at the space camp. John Tufts, The Indianapolis Star, 2 June 2023 In tandem with the aforementioned stranger, Beatrice Steele eagerly sets out to reveal the killer, chaperoned by a female playwright whose voluminous hats hold many surprises. John Tufts covers evening breaking and trending news for the Indianapolis Star. 2023 More:New Indiana State Fair policy requires youth under 18 to be chaperoned after 6 p.m. 2023 So when mom decided to retire, Gina asked her to come back and chaperone the band camp trips. Verb On arrival, she is chaperoned by a cynical uncle (Nagase) to uncover the mystery of her strange dreams and her mother’s disappearance years ago. Victoria Moorwood, The Enquirer, 7 Sep. The chaperone must present a valid ID upon entry. 2023 Under the policy: All guests 15 years old and under must be accompanied by a chaperone who is at least 21 years old to enter or stay in the park after 4 p.m. Lynn Steger Strong, The New Republic, 15 Sep. 2023 As the trial gets going, Sarah is desperate to attend, and, shocking everyone, Eliza offers to function as her chaperone. Farouk to prom under the guise of needing more chaperones. 2023 In the finale, Coach Singh (Chetna Pandya), one of the other openly gay educators at Truham, teasingly tells Mr. 2023 The two stood face to face for some time and the incident ended when a chaperone arrived and told the students to leave. 2023 Taliban regulations do not allow women to travel or move in public spaces unless in the company of male relatives to chaperone. 2023 School officials said the bus was carrying a total of 17 students and three chaperones. 2023 The bus was one of six carrying the Farmingdale High School marching band and their chaperones. Noun Ferrari taught history at Farmingdale High School for more than 30 years and continued to chaperone band trips for years, Newsday reported.
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